Augmentation of 6-Aminonicotinamide Antagonism of Tumor
نویسنده
چکیده
The hormonal derivatives diethylstilbestrol, hexestrol, dienestrol, cortisone, estradiol-17a, estradiol-17/3, progesterone, and phloretin were compared with regard to their capacity to enhance carcinostasis in the presence of the niacin antagonist 6aminonicotinamide. Diethylstilbestrol and hexestrol were found to be more powerful than either estradiol-17/îor dienestrol. Phloretin, estradiol-17a, and progesterone were without activity. Cortisone, either alone or in the presence of 6-aminonicotinamide, exhibited slight antitumor activity. In the absence of 6-aminonicotinamide, diethylstilbestrol, hexestrol, dienestrol, and estradiol-17/3 had no antitumor activity. The suggestive correlation between estrogenic activity and enhancement of carcino stasis in the presence of 6-aminonicotinamide is discussed.
منابع مشابه
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